Phillips Lab

Recent Publications

2018 (Phillips Lab members in bold)

Association of Epidural Stimulation With Cardiovascular Function in an Individual With Spinal Cord Injury #West CR, #Phillips AA, Squair JW, Williams AM, Walter M, Lam T, Krassioukov AV. #Co-first author JAMA Neurology

Journal Club: Relationship between carotid arterial properties and cerebral white matter hyperintensities. Squair JW, Field TS, Phillips AA. Neurology

Alarming blood pressure changes during routine bladder emptying in a woman with cervical spinal cord injury. Lee AHX, Phillips AA, Squair JW, Barak OF, Coombs GB, Ainslie PN, Sarafis ZK, Mijacika, Vucina, Dujic Z, Krassioukov AV. Spinal Cord Ser Cases.

Transient Hypertension after Spinal Cord Injury Leads to Cerebrovascular Endothelial Dysfunction and Fibrosis. Phillips AA, Matin N, Jia M, Squair JW, Monga A, Zheng MMZ, Sachdeva R, Yung A, Hocaloski S, Elliott S, Kozlowski P, Dorrance AM, Laher I, Ainslie PN, Krassioukov AV. J Neurotrauma

Incidence and Natural Progression of Neurogenic Shock after Traumatic Spinal Cord Injury. Ruiz IA, Squair JW, Phillips AA, Lukac CD, Huang D, Oxciano P, Yan D, Krassioukov AV. J Neurotrauma

An Autonomic Neuroprosthesis: Noninvasive Electrical Spinal Cord Stimulation Restores Autonomic Cardiovascular Function in Individuals with Spinal Cord Injury. Phillips AA, Squair JW, Sayenko DG, Edgerton VR, Gerasimenko Y, Krassioukov AV. J Neurotrauma

Research Activities

My research intersects integrated physiology and neuroscience in order to understand cardiovascular function. Currently, the laboratory has two primary foci: the first is to understand the mechanisms underlying neurovascular regulation in the human brain; the second is to develop a neurostimulation therapy for restoring cardiovascular health in those with autonomic dysfunction.

International Collaborations

I am currently working with interdisciplinary teams of scientists, clinicians, and engineers in Switzerland (EPFL), Croatia (Split Medical School), and the USA (University of Minnesota) to deeply understand the capacity of electrical stimulation of the spinal cord to control autonomic function. These studies are using murine models, as well as non-human primates and humans.

Tools

Clinical tools used in the lab include vascular and cardiac ultrasound, beat-by-beat blood pressure, MRI, orthostatic stress testing, arterial blood gas reactivity testing, both surgically implanted and non-invasive neurostimulation modalities, etc. Preclinical tools include various tissue clearing methods (CLARITY, uDISCO) arterial cannulation, nerve recordings, spinal cord transection/contusion, and a variety of genetic strains for manipulation (e.g., Th-Cre, PV-Cre). The lab is also employing a novel computational pipeline for managing large data-sets of physiological metrics.